✦ LIBER ✦

Stoichiometry and Physical Chemistry of Promiscuous Aggregate-Based Inhibitors

✍ Scribed by Coan, Kristin E. D.; Shoichet, Brian K.

Book ID: 121467665
Publisher: American Chemical Society
Year: 2008
Tongue: English
Weight: 252 KB
Volume: 130
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja802977h

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Identification and Prediction of Promisc

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

✍ Seidler, James; McGovern, Susan L.; Doman, Thompson N.; Shoichet, Brian K. 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 271 KB

Identification and Prediction of Promisc

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

✍ Seidler, James; McGovern, Susan L.; Doman, Thompson N.; Shoichet, Brian K. 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 271 KB

Some small molecules, often hits from screening, form aggregates in solution that inhibit many enzymes. In contrast, drugs are thought to act specifically. To investigate this assumption, 50 unrelated drugs were tested for promiscuous inhibition via aggregation. Each drug was tested against three un

Novel Mechanism-Based Inhibitors of Aβ A

Novel Mechanism-Based Inhibitors of Aβ Aggregation and Toxicity

✍ Lashuel, Hilal A.; Eleuteri, Simona; Di Giovanni, Saviana; Rockenstein, Edward; 📂 Article 📅 2014 🏛 Elsevier Science 🌐 English ⚖ 69 KB

Aggregative activation and carbanion che

Aggregative activation and carbanion chemistry : complex base deprotonation and directed functionalisation of dithioacetals

✍ Philippe Gros; Philippe Hansen; Paul Caubére 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 589 KB

Novel oxoisoaporphine-based inhibitors o

Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation

✍ Huang Tang; Hai-Tao Zhao; Shu-Ming Zhong; Zhi-Yu Wang; Zhen-Feng Chen; Hong Lian 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 688 KB

Novel Donepezil-Based Inhibitors of Acet

Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

✍ Camps, Pelayo; Formosa, Xavier; Galdeano, Carles; Gómez, Tània; Muñoz-Torrero 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 683 KB