✦ LIBER ✦

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

✍ Scribed by Seidler, James; McGovern, Susan L.; Doman, Thompson N.; Shoichet, Brian K.

Book ID: 118008653
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 271 KB
Volume: 46
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm030191r

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Identification and Prediction of Promisc

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

✍ Seidler, James; McGovern, Susan L.; Doman, Thompson N.; Shoichet, Brian K. 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 271 KB

Some small molecules, often hits from screening, form aggregates in solution that inhibit many enzymes. In contrast, drugs are thought to act specifically. To investigate this assumption, 50 unrelated drugs were tested for promiscuous inhibition via aggregation. Each drug was tested against three un

Identification of known drugs that act a

Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action

✍ Susanne C. Miller; Ruili Huang; Srilatha Sakamuru; Sunita J. Shukla; Matias S. A 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 462 KB

370 Identification of IGF1R as a Predict

370 Identification of IGF1R as a Predictive Biomarker for Intrinsic Resistance to PI3K Inhibitors and a Therapeutic Target for Improving the Drug Efficacy

✍ Dan, S.; Isoyama, S.; Nishimura, Y.; Kajiwara, G.; Nakamura, N.; Yamori, T. 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 58 KB