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Stoffwechselprodukte von Mikroorganismen. 178. Mitteilung. Die Avilamycine A und C: Chemischer Abbau und spektroskopische Untersuchungen

✍ Scribed by Walter Keller-Schierlein; William Heilman; W. David Ollis; Christopher Smith

Publisher
John Wiley and Sons
Year
1979
Tongue
German
Weight
879 KB
Volume
62
Category
Article
ISSN
0018-019X

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✦ Synopsis

Hydrolysis and methanolysis of Avilamycin C yielded a series of mono‐ and oligosaccharide‐like products, which were, with one exception, identical with degradation products of flambamycin. Instead of evalose (6‐deoxy‐3‐methyl‐D‐mannose), a building stone of Flambamycin and Everninomicin B, evermicose (2, 6‐dideoxy‐3‐methyl‐D‐mannose) was identified as a constituent of the Avilamycins. This sugar was known as a degradation product of the Everninomicins C and D. From the degradation results a structure of Avilamycin A was postulated which differs from that of Flambamycin only by the lack of a hydroxyl group in position 2 of the evalose residue. This hypothesis was confirmed by a careful ^1^H‐ and ^13^C‐NMR. study.

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