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Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors

✍ Scribed by Dagmar Meyer zu Heringdorf; Holger Lass; Igor Kuchar; Mathias Lipinski; Regina Alemany; Ulrich Rümenapp; Karl H Jakobs

Book ID
114013736
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
616 KB
Volume
414
Category
Article
ISSN
0014-2999

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## Abstract The lysophospholipid growth factors sphingosine 1‐phosphate (S1P) and lysophosphatidic acid (LPA) are generated by many cells involved in immunity, including macrophages, dendritic cells, mast cells, and platelets, with resultant lymph and plasma concentrations of 0.1–1 μM. All immune c