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Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells

✍ Scribed by Tiina M. Asikainen; Aftab Ahmad; Barbara K. Schneider; Wen-Bin Ho; Michael Arend; Mitchell Brenner; Volkmar Günzler; Carl W. White

Book ID: 113629483
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 415 KB
Volume: 38
Category: Article
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2004.12.004

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## Abstract We examined how ionizing radiation (IR) delivered under either severe hypoxia (< 0.1% O~2~) or normoxia affects the expression of hypoxia inducible factor 1α (HIF‐1α) and the angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietins 1, 2 and 4 in U87 human glioblast