✦ LIBER ✦

Stimulation of endothelial cell proliferation by vanadate is specific for microvascular endothelial cells

✍ Scribed by Pamela A. Maher

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 724 KB
Volume: 151
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041510314

No coin nor oath required. For personal study only.

✦ Synopsis

Micromolar conccntrations of sodium orthovanadate 5timulated the proliferation of bovine capillary endothelial cclls, but no1 bovine aortic endothelial cells. Vanadate was equally potent at inducing protein tyrosine phosphorylation and changes in morphology in both types of cells. However, vanadatc treatment lead to an inhibition of protein tyrosine kinase activity in the aortic endothelial cells, but not the capillary endothelial cells. In capillary endothelial cells, the effect of vanadatc was additive with basic FGF (bFGF) at low concentrations of bFGF. There was no interaction between bFGF and vanadate in aortic endothelial cells. TGF-p, which inhibits the induction of endothelial cell proliferation by bFGF, appeared to shift the dose response curve to vanadate in capillary endothelial cells, increasing the proliferative effect of vanadate at low vanadate concentrations, but decreasing the proliferative effect a1 higher vanadate concentrations. B 1992 Wiley-Liss, Inc

Methods

Cell culture and mitogenic agents Bovine aortic endothelial (ABAE) cells were prepared from the aortic arch and cultured as described

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