✦ LIBER ✦

Proliferation and neurogenesis of neural stem cells enhanced by cerebral microvascular endothelial cells

✍ Scribed by Ying Guo; Dejin Shi; Wensheng Li; Chaofeng Liang; Hui Wang; Zhuopeng Ye; Liping Hu; Hua-Qiao Wang; Yan Li

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 322 KB
Volume: 28
Category: Article
ISSN: 0738-1085
DOI: 10.1002/micr.20443

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In adult mammalian brain, vascular cells reside throughout life, close to central nervous system germinal zones, and neural stem cells (NSCs) mainly localize in the dentate gyrus of the hippocampus, subventricular zone, and olfactory bulb. Microvessels appear to produce a special microenvironment that may influence the characteristics of NSCs. To explore this potential correlation, an in vitro model with cocultured cerebral microvascular endothelial cells (CMECs) and NSCs was established in our study by using a transwell coculture system. The expression of nestin and NF in the early stage of coculture, and NF in the late stage, was detected by immunostaining. The results demonstrated that CMECs can stimulate self‐renewal of NSCs and inhibit their differentiation, implying the potential of CMECs in promoting the neural differentiation of NSCs. © 2007 Wiley‐Liss, Inc. Microsurgery, 2008.

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