✦ LIBER ✦

Steroide, lix. Tritiummarkierung eines neuen Hochwirksamen Gestagens: STS 557 [14α,15α-3H]-17α-cyanomethyl-17ß-hydroxy-Östra-4,9-dien-3-on

✍ Scribed by H. Wagner; J. Römer; M. Hübner; K. Ponsold

Book ID: 102900906
Publisher: John Wiley and Sons
Year: 1980
Tongue: French
Weight: 527 KB
Volume: 17
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580170302

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✦ Synopsis

Abstract

The preparation of [14α,15α‐^3^H]‐17α‐cyanomethyl‐17ß‐hydroxy‐estra‐4,9‐diene‐3‐one (X) starting with catalytic tritiation of 3‐methoxy‐estra‐1,3,5(10),8,14‐pentaene‐17ß‐ol (I) and followed by a ten‐step synthesis is described. This new high effective gestagene STS 557 was obtained with high specific aotivity and radioohemioal purity better than 98 % Radiolysis and storage conditions are examined.

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