This paper describes the rational design and synthesis of novel inhibitors of human steroid 5a-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5a-reductase isozymes. Judicious placement of the nitrone i
✦ LIBER ✦
Steroidal inhibitors of prostatic 5α-reductase: Structure-activity relationships
✍ Scribed by G.M. Dupuy; K.D. Roberts; G. Bleau; A. Chapdelaine
- Book ID
- 116000863
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 513 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0022-4731
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