This paper describes the rational design and synthesis of novel inhibitors of human steroid 5a-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5a-reductase isozymes. Judicious placement of the nitrone i
✦ LIBER ✦
Selective non-steroidal inhibitors of 5α-reductase type 1
✍ Scribed by Ernesto G. Occhiato; Antonio Guarna; Giovanna Danza; Mario Serio
- Book ID
- 116697249
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 229 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0960-0760
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Steroidal nitrone inhibitors of 5α-reduc
✍
Andrea J Robinson; Indawati DeLucca; Spencer Drummond; George A Boswell
📂
Article
📅
2003
🏛
Elsevier Science
🌐
French
⚖ 106 KB
A comparison of steroidal and non-steroi
✍
Andrew D. Abell; Martin Brandt; Mark A. Levy; Dennis A. Holt
📂
Article
📅
1996
🏛
Elsevier Science
🌐
English
⚖ 231 KB
ChemInform Abstract: Synthesis of Benzo[
✍
A. GUARNA; E. G. OCCHIATO; D. SCARPI; R. TSAI; G. DANZA; A. COMERCI; R. MANCINA;
📂
Article
📅
2010
🏛
John Wiley and Sons
⚖ 33 KB
👁 2 views
ChemInform Abstract: Comparison of Stero
✍
A. D. ABELL; M. BRANDT; M. A. LEVY; D. A. HOLT
📂
Article
📅
2010
🏛
John Wiley and Sons
⚖ 35 KB
A non-steroidal diene acid inhibitor of
✍
Andrew D. Abell; Martin Brandt; Mark A. Levy; Dennis A. Holt
📂
Article
📅
1994
🏛
Elsevier Science
🌐
English
⚖ 261 KB
A series of 4a-methyl-3,4,4a,9-tetrahycIrophenanthrene-2-carhoxyllc acids aud 2-phosphiuic acids has heen prepared and evaluated in vitro as inhibitors of human recombinant steroid Sa-reductase. 7-Chloro-4amethyl-3,4,4a,9-tetrahydrophenauthrene-2-csrhoxylic acid, 5, is a marginally sclectlve inhibit
Steroidal inhibitors of prostatic 5α-red
✍
G.M. Dupuy; K.D. Roberts; G. Bleau; A. Chapdelaine
📂
Article
📅
1978
🏛
Elsevier Science
🌐
English
⚖ 513 KB