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A non-steroidal diene acid inhibitor of human type 2 stereoid 5α-reductase

✍ Scribed by Andrew D. Abell; Martin Brandt; Mark A. Levy; Dennis A. Holt

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
261 KB
Volume
4
Category
Article
ISSN
0960-894X

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✦ Synopsis

A series of 4a-methyl-3,4,4a,9-tetrahycIrophenanthrene-2-carhoxyllc acids aud 2-phosphiuic acids has heen prepared and evaluated in vitro as inhibitors of human recombinant steroid Sa-reductase. 7-Chloro-4amethyl-3,4,4a,9-tetrahydrophenauthrene-2-csrhoxylic acid, 5, is a marginally sclectlve inhibitor of human type 2 steroid Sa-reductase (K.

-260 &I). The phosphinic acid compounds, 8 and 9, are weak inhibitors of types 1 and 2 steroid Scz-reductrk?p -

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