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Steroid-independent activation of androgen receptor in androgen-independent prostate cancer: A possible role for the MAP kinase signal transduction pathway?

✍ Scribed by X Zhu; J.-P Liu


Book ID
117463795
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
358 KB
Volume
134
Category
Article
ISSN
0303-7207

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## Abstract Androgen receptor (AR) mutations that modify both the ligand binding and the transactivation capacities of the AR represent one of the mechanisms involved in the transition of prostate cancer (PCa) from androgen‐dependent to androgen‐independent growth. We use a yeast‐based functional a