Primary aliphatic amines on oxidation with iodosobenzene in CH2C12 or H20 yield the corresponding nitriles, while primary cycloalkylamines give the corresponding cyclic ketones. Lactams are obtained by the oxidation of cyclic amines. (S)(-) Nicotine (JJ,) is oxidized to (+)-cotinine (a). The interm
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Steric effects in the hypervalent iodine oxidation of ketones
โ Scribed by Robert M. Moriarty; Indra Prakash; H.A. Musallam
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 183 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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## Hypervalent iodine oxidation of aryl methyl ketones using two equivalents of iodosobenzene diacetate leads to 1.2-aryl migration followed by solvohyperiodination to yield the corresponding methyl a-methoxyarylacetates.
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