Stereospecific synthesis of (+)-L-erythro-4-fluoroglutamic acid. Tema con variazioni.
✍ Scribed by Milos Hudlicky
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 50 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-1139
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✦ Synopsis
The third stereoisomer of 4-fluoroglutamic acid, (+)-L-eryrhro-4-fluoroglutamic acid, was
📜 SIMILAR VOLUMES
Enantiomerically pure L-erythroand L-threo-4-fluoroglutamic acids la and lb were conveniently prepared. The key steps in this synthesis relied upon separation of diastereomers of N-chloroacetyl-4-fluoroglutamic acid 5-methyl ester 7 by recrystallization and enzymatic resolution of enantiomers of the
Abrrracr . Stereospecific syntheses of (+)-L-rlrreo and (-)-D-eryrhro-4-fluoroglutamic acid am based on the hydrolysis of methyl l-acetyl-4-fluoro-L-pyrroklin-5-one-2-carboxylate, prepared from rrans-and cis-4hydmxyproliues, respectively. After the discovery of the antimetabolic properties of fluoro
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## Abstract 4‐[^2^H~2~]‐L‐glutamic acid was prepared in excellent yield by enzymatic reductive amination of 4‐[^2^H~2~]‐2‐ketoglutaric acid. The synthesis of stereospecifically deuterated (4 R) and (4 S)‐[4‐^2^H~2~]‐L‐glutamic acids from (2 RS, 4 S) and (2 RS, 4 R)‐4‐hydroxyglutamic acids, involvin
The title compounds, required for the identification of structural features of the Bordetella pertussis endotoxin, have been synthesised by condensation of benzyl 3-O-benzyl-2-deoxy-beta-L-erythro-pentopyranoside with 2,3,4,6-tetra-O-benzoyl-alpha-D-mannopyranosyl bromide and with 4,6-di-O-acetyl-2,