The third stereoisomer of 4-fluoroglutamic acid, (+)-L-eryrhro-4-fluoroglutamic acid, was
Stereospecific synthesis of 4-fluoroglutamic acids
β Scribed by Anthony G. Avent; Andrew N. Bowler; Paul M. Doyle; Christina M. Marchand; Douglas W. Young
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 256 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Enantiomerically pure L-erythroand L-threo-4-fluoroglutamic acids la and lb were conveniently prepared. The key steps in this synthesis relied upon separation of diastereomers of N-chloroacetyl-4-fluoroglutamic acid 5-methyl ester 7 by recrystallization and enzymatic resolution of enantiomers of the
Abrrracr . Stereospecific syntheses of (+)-L-rlrreo and (-)-D-eryrhro-4-fluoroglutamic acid am based on the hydrolysis of methyl l-acetyl-4-fluoro-L-pyrroklin-5-one-2-carboxylate, prepared from rrans-and cis-4hydmxyproliues, respectively. After the discovery of the antimetabolic properties of fluoro