Enantiomerically pure L-erythroand L-threo-4-fluoroglutamic acids la and lb were conveniently prepared. The key steps in this synthesis relied upon separation of diastereomers of N-chloroacetyl-4-fluoroglutamic acid 5-methyl ester 7 by recrystallization and enzymatic resolution of enantiomers of the
ChemInform Abstract: Practical Synthesis of L-erythro- and L-threo-4-Fluoroglutamic Acids ( V) Using Aminoacylase.
β Scribed by Y. KOKURYO; T. NAKATANI; K. KOBAYASHI; Y. TAMURA; K. KAWADA; M. OHTANI
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 27 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable via the βReferencesβ option.
π SIMILAR VOLUMES
Abrrracr . Stereospecific syntheses of (+)-L-rlrreo and (-)-D-eryrhro-4-fluoroglutamic acid am based on the hydrolysis of methyl l-acetyl-4-fluoro-L-pyrroklin-5-one-2-carboxylate, prepared from rrans-and cis-4hydmxyproliues, respectively. After the discovery of the antimetabolic properties of fluoro
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v