Stereospecific internal alkylation of terminal γ,δ-epoxy acrylates
✍ Scribed by Masahiro Miyazawa; Naoki Ishibashi; Satoshi Ohnuma; Masaaki Miyashita
- Book ID
- 104256999
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 219 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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Highly efficient and stereospecific construction of asymmetric quaternary carbons via the alkylation of y-alkyl-y,~-epoxy acrylates with (CH3)3A1 is described.
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The synthesis of the C(19) -C(32) fragment of Scytophycin C is described which features an iterative, stereospecific methylation of y,8-epoxy acrylates by trimethylaluminum and the use of Roush's (S,S)diisopropyltartrate-E-crotylboronate.
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