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Stereoselectivity of isozyme C of glutathione S-transferase toward arene and azaarene oxides

โœ Scribed by Cobb, Diane; Boehlert, Charles; Lewis, Deborah; Armstrong, Richard N.

Book ID
126197086
Publisher
American Chemical Society
Year
1983
Tongue
English
Weight
984 KB
Volume
22
Category
Article
ISSN
0006-2960

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Glutathione S-transferases (GST, E.C.2.5.1.18) comprise a family of detoxification enzymes. Elevated levels of specific GST isozymes in tumor cells are thought responsible for resistance to chemotherapeutics, which renders selective GST inhibitors potentially useful pharmaceutical agents. We discuss