Isozyme selective arylation of cytosolic glutathione S-transferase by [14C]bromobenzene metabolites
β Scribed by Yoko Aniya; John C. McLenithan; M.W. Anders
- Book ID
- 115780694
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 940 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0006-2952
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π SIMILAR VOLUMES
Purification of glutathione S-transferases A and C from rat liver cytosol using an affinity matrix coupled with cholic acid is described. The method provides a convenient means for the rapid and homogeneous preparation of both transferases.
Ochratoxin A (OTA), a mycotoxin that induces nephrotoxicity and urinary tract tumors, is genotoxic and can be metabolized not only by different cytochromes P450 (CYP) but also by peroxidases involved in the arachidonic cascade, although the exact nature of the metabolites involved in the genotoxic p