Stereoselectivity in pharmacokinetics of tiaprofenic acid: response
✍ Scribed by Françoise Lapicque; Didier Mainard; Pierre Gillet; Elisabeth Payan; Bernard Bannwarth; Patrick Netter
- Book ID
- 105922659
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 99 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0031-6970
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📜 SIMILAR VOLUMES
The pharmacokinetics and metabolic chiral inversion of the S(+)-and R(-)-enantiomers of tiaprofenic acid (S -TIA, R-TIA) were assessed in vivo in rats, and in addition the biochemistry of inversion was investigated in vitro in rat liver homogenates. Drug enantiomer concentrations in plasma were inve
Twelve healthy children in three age groups anaesthetized for minor surgery were given a single oral dose of tiaprofenic acid (3 mg.kg-1) (TA). Seven blood samples and zero to 8 and 8 to 24 h urines were collected. TA concentrations in plasma and urine were measured by HPLC. No significant differenc