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Lack of significant stereoselectivity in pharmacokinetics of tiaprofenic acid

✍ Scribed by Fakhreddin Jamali

Book ID
105922658
Publisher
Springer
Year
1997
Tongue
English
Weight
82 KB
Volume
52
Category
Article
ISSN
0031-6970

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The pharmacokinetics and metabolic chiral inversion of the S(+)-and R(-)-enantiomers of tiaprofenic acid (S -TIA, R-TIA) were assessed in vivo in rats, and in addition the biochemistry of inversion was investigated in vitro in rat liver homogenates. Drug enantiomer concentrations in plasma were inve

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Twelve healthy children in three age groups anaesthetized for minor surgery were given a single oral dose of tiaprofenic acid (3 mg.kg-1) (TA). Seven blood samples and zero to 8 and 8 to 24 h urines were collected. TA concentrations in plasma and urine were measured by HPLC. No significant differenc