The chiral beta-blocker acebutolol (AC) is marketed as a racemic mixture. Both AC and its major metabolite, diacetotol (DC), are chiral, the S-enantiomer possessing beta-blocking activity. The pharmacokinetics of AC and DC enantiomers was determined in 12 healthy subjects following oral administrati
Pharmacokinetics of the enantiomers of tiaprofenic acid in humans
โ Scribed by Nikhilesh N. Singh; Fakhreddin Jamali; Franco M. Pasutto; Anthony S. Russell; Ronald T. Coutts; Keith S. Drader
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 400 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
The pharmacokinetics and metabolic chiral inversion of the S(+)-and R(-)-enantiomers of tiaprofenic acid (S -TIA, R-TIA) were assessed in vivo in rats, and in addition the biochemistry of inversion was investigated in vitro in rat liver homogenates. Drug enantiomer concentrations in plasma were inve
A stereoselective and sensitive achirdchiral method for the determination of terfenadine acid metabolite in human plasma was developed. The metabolite was separated and quantitated using an achiral chromatographic procedure with a cyano column. The mobile phase was 1 mM sodium acetate buffer (pH 4.0
The steady-state pharmacokinetics in serum and urine of the enantiomers of citalopram and its metabolites, demethylcitalopram (DCT) and didemethylcitalopram (DDCT), were investigated after multiple doses of rac-citalopram for 21 consecutive days (40 mg per day) to healthy human subjects who were ext