Stereoselective Total Synthesis of Serine Palmitoyl-CoA Transferase Inhibitors
✍ Scribed by Hoe-Sup Byun; Xuequan Lu; Robert Bittman
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 8 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The syntheses of long chain alkyl‐coenzyme A derivatives**1** and**2** are reported. Heptadecan‐2‐onyldethio‐CoA**(1)** a carba analog of __S__‐palmitoyl‐CoA is obtained along with its 2′‐phosphate isomer**11** by the condensation of adenosine 2′,3′‐cyclic phosphate‐5′‐phosphoromorpholi