The use of phosphorothioates as DNA analogues useful in antisense-based therapy is well established and led to the development of Vitravene as the first antisense drug. Several other phosphorothioate oligonucleotides (PS-Oligos) are in clinical trials. Although Stec et al. described an elegant oxa
Stereoselective Synthesis of α- and β-Glycosylamide Derivatives from Glycopyranosyl Azides via Isoxazoline Intermediates.
✍ Scribed by Fehmi Damkaci; Philip DeShong
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 123 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
The use of phosphorothioates as DNA analogues useful in antisense-based therapy is well established [1] and led to the development of Vitravene as the first antisense drug. [2] Several other phosphorothioate oligonucleotides (PS-Oligos) are in clinical trials. Although Stec et al. described an elega
## Abstract Under appropriate reaction conditions, a domino hydroformylation/Wittig olefination can be accomplished with derivatives of allylamines and stabilized Wittig ylides. A further highly diastereoselective aza‐Michael reaction yields β‐proline derivatives. These are, for example, useful as