ChemInform Abstract: Stereoselective Synthesis of β-Proline Derivatives from Allylamines via Domino Hydroformylation/Wittig Olefination and Aza-Michael Addition.

Stereoselective Synthesis of β-Proline D

Stereoselective Synthesis of β-Proline Derivatives from Allylamines via Domino Hydroformylation/Wittig Olefination and Aza-Michael Addition

✍ Andreas Farwick; Günter Helmchen 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 298 KB 👁 1 views

## Abstract Under appropriate reaction conditions, a domino hydroformylation/Wittig olefination can be accomplished with derivatives of allylamines and stabilized Wittig ylides. A further highly diastereoselective aza‐Michael reaction yields β‐proline derivatives. These are, for example, useful as