Stereoselective Synthesis of β-Proline Derivatives from Allylamines via Domino Hydroformylation/Wittig Olefination and Aza-Michael Addition

✍ Scribed by Andreas Farwick; Günter Helmchen

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 298 KB
• Volume: 352
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.201000016

✦ Synopsis

Abstract

Under appropriate reaction conditions, a domino hydroformylation/Wittig olefination can be accomplished with derivatives of allylamines and stabilized Wittig ylides. A further highly diastereoselective aza‐Michael reaction yields β‐proline derivatives. These are, for example, useful as building blocks for alkaloid syntheses.