Stereoselective Synthesis of Threo and Erythro β-Hydroxy and β-Disubstituted-β-Hydroxy α-Amino Acids
✍ Scribed by Blaskovich, Mark A.; Evindar, Ghotas; Rose, Nicholas G. W.; Wilkinson, Scott; Luo, Yue; Lajoie, Gilles A.
- Book ID
- 111864953
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 260 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
The recent findings of Campbell et al. (I) regarding the action of L-asparaginase on various asparagine-requiring tumours have prompted the syntheses and investigation of analogues of this amino acid (2). We wish to report the preparation of the F-amides of three-and erythr@-~-hydroxy-L-aspartic ac
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Ihe amino acids (-)-erythro-and (-)-threo-ylqdrcqnorvaline have been synthesized fran D-ribonolactone, 6, as single chira-cursor. Moreover, S-hydroxy-uazido-rvalerolactones 1Za and 12b have been also prepared from 6 in two different alternative ways. These compounds afford B,y-dihydroxy~~-amino aci