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Stereoselective synthesis of the decahydrofluorene core of the hirsutellones

✍ Scribed by Geoff T. Halvorsen; William R. Roush

Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
683 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis

A stereoselective synthesis of the decahydrofluorene core of the hirsutellones was accomplished in eight steps and in 43% overall yield. The key step of the synthesis is the highly stereoselective intramolecular Diels-Alder cyclization of the siloxacyclopentene-constrained tetraene 1.

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