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Stereoselective Synthesis of the Cytotoxic 14-Membered Macrolide Aspergillide A

✍ Scribed by Díaz-Oltra, Santiago; Angulo-Pachón, César A.; Murga, Juan; Carda, Miguel; Marco, J. Alberto

Book ID
127280985
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
806 KB
Volume
75
Category
Article
ISSN
0022-3263

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Stereoselective synthesis of the cytotox
Stereoselective synthesis of the cytotoxic macrolide aspergillide B
✍ Santiago Díaz-Oltra; César A. Angulo-Pachón; María N. Kneeteman; Juan Murga; Mig 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 274 KB

A total, stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. A cross metathesis and a C-glycosidation via a Mukaiyama-type aldol reaction were key features of the synthesis. The macrocyclic lactone ring was created by means of the Yamaguchi procedure.