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Stereoselective Synthesis of the Cytotoxic Macrolide FD-891 †

✍ Scribed by García-Fortanet, Jorge; Murga, Juan; Carda, Miguel; Marco, J. Alberto

Book ID
125935955
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
103 KB
Volume
8
Category
Article
ISSN
1523-7060

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Stereoselective synthesis of the cytotox
Stereoselective synthesis of the cytotoxic macrolide aspergillide B
✍ Santiago Díaz-Oltra; César A. Angulo-Pachón; María N. Kneeteman; Juan Murga; Mig 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 274 KB

A total, stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. A cross metathesis and a C-glycosidation via a Mukaiyama-type aldol reaction were key features of the synthesis. The macrocyclic lactone ring was created by means of the Yamaguchi procedure.