## Abstract α‐Alkylation of the α,β‐unsaturated ketone 1 at C‐4 has been achieved by thioalkylation of the corresponding zinc dienolate with α‐chlorosulfides of type 2. The desulfurization of the β‐(phenylthio) ketones 4 leads directly to the 4‐substituted hexahydroinden‐5‐ones 5. magnified image
Stereoselective Synthesis of Steroids and Related Compounds, III. Synthesis of Enantiomerically Pure Hexahydro-1H-indenes and Substituted Cyclopentanes as Intermediates for the Synthesis of Steroids
✍ Scribed by Groth, Ulrich ;Taapken, Thomas
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 279 KB
- Volume
- 1994
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
The indene derivative 7 and the 1,2,2,3‐tetrasubstituted cyclopentane derivative 8 have been synthesized in three steps starting from the Hajos‐Wiechert ketone 1. magnified image
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