✦ LIBER ✦
Thioalkylation of Enolates, III. Stereoselective Synthesis of Steroids and Related Compounds, II α-Thioalkylation of Zinc Dienolates to 4-Substituted 1-tert-Butoxy-7a-methyl-hexahydroinden-5-ones
✍ Scribed by Groth, Ulrich ;Köhler, Thomas ;Taapken, Thomas
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 484 KB
- Volume
- 1994
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
α‐Alkylation of the α,β‐unsaturated ketone 1 at C‐4 has been achieved by thioalkylation of the corresponding zinc dienolate with α‐chlorosulfides of type 2. The desulfurization of the β‐(phenylthio) ketones 4 leads directly to the 4‐substituted hexahydroinden‐5‐ones 5. magnified image