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Stereoselective synthesis of sphinganine by means of modified asymmetric borane reduction

✍ Scribed by Moriyasu Masui; Takayuki Shioiri

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 141 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01020-x

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✦ Synopsis

Efficient stereoselective synthesis of sphinganine by the asymmetric borane reduction of ctoxoketoxime trityl ethers is described. Both threo and erythro sphinganine could be obtained with high enantioselectivities by using borane-N,N-diethylaniline complex as a reducing agent.

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