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Stereoselective Synthesis of Quaternary Proline Analogues

โœ Scribed by M. Isabel Calaza; Carlos Cativiela


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
1007 KB
Volume
2008
Category
Article
ISSN
1434-193X

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Efficient and stereoselective synthesis
โœ Junyi Zhang; Wei Wang; Chiyi Xiong; Victor J. Hruby ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 222 KB

A series of novel cis-4-substituted proline analogues were designed and synthesized. Highly stereoselective alkylations at the g-position of glutamic ester 2 were achieved, followed by reduction, mesylation, and cyclization to afford the title compounds 1 in good yields and high diastereoselectivity