Efficient and stereoselective synthesis of novel cis-4-substituted proline analogues

✍ Scribed by Junyi Zhang; Wei Wang; Chiyi Xiong; Victor J. Hruby

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 222 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02865-4

✦ Synopsis

A series of novel cis-4-substituted proline analogues were designed and synthesized. Highly stereoselective alkylations at the g-position of glutamic ester 2 were achieved, followed by reduction, mesylation, and cyclization to afford the title compounds 1 in good yields and high diastereoselectivity.