𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Stereoselective Synthesis of Novel anti-MRSA Tricyclic Carbapenems (Trinems)

✍ Scribed by Osamu Kanno; Isao Kawamoto

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
191 KB
Volume
56
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.

✦ Synopsis

AbstractÐ(4S)-Hydroxymethyltrinem 3 was prepared via stereoselective aldol-type reaction with optically pure (R)-2-t-butyldimethylsilyloxymethylcyclohexanone ((R)-16). (4S)-Hydroxymethyltrinem 3 was converted into various kinds of trinem derivatives with anti-MRSA activity by using the Mitsunobu reaction.

πŸ“œ SIMILAR VOLUMES

Synthesis and antibacterial activity of
Synthesis and antibacterial activity of lipophilic carbapenems with anti-MRSA activity
✍ Jean Claude Arnould; Ruth N Illingworth; Wright W Nichols; R. Geoffrey Wilson πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 326 KB

A series of sulphur-linked and carbon-linked lipophLlic carhapenems has been prepared and evaluated for antibacterial activity in vitro and in vivo and for affinity for PBP2' of Staphylococcus aureus. Potent activity in vitro against methicillin-resistant S. aureus and methicillin-resistant coagulas