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Stereoselective synthesis of multiply substituted [1,2]oxazinan-3-ones via ring-closing metathesis

✍ Scribed by Shustov, Gennady V; Chandler, Melanie K; Wolfe, Saul


Book ID
111657938
Publisher
NRC Research Press
Year
2005
Tongue
French
Weight
266 KB
Volume
83
Category
Article
ISSN
0008-4042

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The 1-benzazepin-2-one ring system is an important structural feature of marketed drugs, clinical candidates, and other bioactive molecules. We have developed a new benzazepinone synthesis that employs ring-closing olefin metathesis as a key step. This route provides efficient access to substituted