Stereoselective synthesis of highly substituted 8-oxabicyclo[3.2.1]octanes and 2,7-dioxatricyclo[4.2.1.03,8]nonanes
β Scribed by Dmitry A. Khlevin; Sergey E. Sosonyuk; Marina V. Proskurnina; Nikolay S. Zefirov
- Book ID
- 116909477
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 642 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0040-4020
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Starting from 1,1-bisbenzyloxy propanone four oxetanes A, B, C and D representing the dioxatricyclic core of dictyoxetane were synthesized. All of them show a cytotoxic/cytostatic effect using a human gastric carcinoma and a human heptocellular cell line. The activity is comparable to that of5-fluor
The title compound, C 8 H 9 NO 5 , was prepared as a by-product in synthetic efforts to prepare a carbasugar analogue of a putative intermediate, viz. (AE)-6-hydroxymethyl-7-oxabicyclo[2.2.1]hept-2-exo-3-endo-diol, in the uridine diphosphate-galactopyranose mutase-catalysed reaction. The structure s