Stereoselective synthesis of functionalized olefins: The orthoester claisen rearrangement of alkynyl allylic alcohols
โ Scribed by Kathlyn A. Parker; Raymond W. Kosley Jr.
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 181 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
Enantioselective Synthesis of ฮฒ-Substituted Butyric Acid Derivatives via Orthoester Claisen Rearrangement of Enzymatically Resolved Allylic Alcohols: Application to the Synthesis of (R)-(-)-Baclofen. -A three step synthesis of the GABA B receptor agonist (-)-baclofen is presented. Key step in this
Claisen rearrangement of ally1 vinyl ethers is an important general method of carboncarbon bond formation for synthesis of y,b-unsaturated aldehydes and ketones. 1 Syntheses of y,b-unsaturated esters and amides are similarly achieved by rearrangements of 2-alkoxy and 2amino-3-oxa-1,5-hexadienes.