✦ LIBER ✦
ChemInform Abstract: Enantioselective Synthesis of β-Substituted Butyric Acid Derivatives via Orthoester Claisen Rearrangement of Enzymatically Resolved Allylic Alcohols: Application to the Synthesis of (R)-(-)-Baclofen.
✍ Scribed by E. BRENNA; N. CARACCIA; C. FUGANTI; C. FUGANTI; D. FUGANTI; P. GRASSELLI
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 36 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Enantioselective Synthesis of β-Substituted Butyric Acid Derivatives via Orthoester Claisen Rearrangement of Enzymatically Resolved Allylic Alcohols: Application to the Synthesis of (R)-(-)-Baclofen.
-A three step synthesis of the GABA B receptor agonist (-)-baclofen is presented. Key step in this synthesis is the orthoester Claisen rearrangement of enantiomerically pure allylic alcohol ((S)-(-)-I).