Stereoselective synthesis of chiral, non-racemic 1,2,3-tri- and 1,3-disubstituted ferrocene derivatives
✍ Scribed by Steurer, Marianne; Tiedl, Karin; Wang, Yaping; Weissensteiner, Walter
- Book ID
- 120312583
- Publisher
- Royal Society of Chemistry
- Year
- 2005
- Tongue
- English
- Weight
- 260 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1359-7345
- DOI
- 10.1039/B508761A
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Optically pure 2,6-disubstituted morpholines 11 have been obtained by diastereoselective alkylation of 6-substituted 3-oxo morpholines I derived from (R)-(-)-phenylglycinol and a series of chiral epoxides.
During our on-going program dealing with the asymmetric synthesis of biologically active compounds, we previously reported the efficient and enantiomerically selective synthesis of 3-substituted piperidines (2a), 3 and 3-substituted piperazines (2b) 4 by diastereoselective alkylation of chiral non-r