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Stereoselective synthesis of 1,3-disubstituted hexahydro-1,4-diazepin-2-ones

✍ Scribed by Adriana Pohlmann; Dominique Guillaume; Jean-Charles Quirion; Henri-Philippe Husson

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 143 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01291-4

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✦ Synopsis

During our on-going program dealing with the asymmetric synthesis of biologically active compounds, we previously reported the efficient and enantiomerically selective synthesis of 3-substituted piperidines (2a), 3 and 3-substituted piperazines (2b) 4 by diastereoselective alkylation of chiral non-racemic 6-membered lactams

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