Stereoselective synthesis of 2,6-disubstituted morpholines from chiral non-racemic lactams

✍ Scribed by Estelle Bouron; Géraldine Goussard; Christophe Marchand; Martine Bonin; Xavier Panneconcke; Jean-Charles Quirion; Henri-Philippe Husson

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 241 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)01530-0

✦ Synopsis

Optically pure 2,6-disubstituted morpholines 11 have been obtained by diastereoselective alkylation of 6-substituted 3-oxo morpholines I derived from (R)-(-)-phenylglycinol and a series of chiral epoxides.