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Asymmetric synthesis. XL. 2,3-Disubstituted piperidines via chiral non-racemic lactams

✍ Scribed by Lauren Micouin; Jean-Charles Quirion; Henri-Philippe Husson


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
225 KB
Volume
37
Category
Article
ISSN
0040-4039

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Stereoselective synthesis of 2,6-disubst
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Optically pure 2,6-disubstituted morpholines 11 have been obtained by diastereoselective alkylation of 6-substituted 3-oxo morpholines I derived from (R)-(-)-phenylglycinol and a series of chiral epoxides.