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Asymmetric synthesis. XXXIX.1 Synthesis of 3-substituted piperidin-2-ones from chiral non-racemic lactams

✍ Scribed by Laurent Micouin; Martine Bonin; Marie-Pierre Cherrier; Alain Mazurier; Alain Tomas; Jean-Charles Quirion; Henri-Philippe Husson


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
466 KB
Volume
52
Category
Article
ISSN
0040-4020

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Optically pure 2,6-disubstituted morpholines 11 have been obtained by diastereoselective alkylation of 6-substituted 3-oxo morpholines I derived from (R)-(-)-phenylglycinol and a series of chiral epoxides.