Syntheses of xestodecalactone C and epi-sporostatin are described utilising Prins cyclisations, Mitsunobu reaction and intramolecular Friedel-Crafts acylation. The approach is convergent and highly stereoselective.
Stereoselective synthesis of basiliskamides A and B via Prins cyclisation
β Scribed by J.S. Yadav; P. Purushothama Rao; M. Sridhar Reddy; A.R. Prasad
- Book ID
- 104095596
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 170 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A stereoselective and convergent approach to basiliskamides A and B is achieved through our recently developed strategy for the construction of polyketide precursors via Prins cyclisation. The approach mainly relies upon reductive opening of 1-iodomethyl cyclic ethers, Mitsunobu inversion, Takai olefination and Stille coupling along with Prins cyclisation.
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