An acid-catalysed rearrangement of the THP-ether of homoallylic alcohol gives ready access to an O-protected derivative of 4-hydroxytetrahydropyran and thence by two further steps to provide a short and highly stereoselective route to the title spiroketal.
Spiroketals: a total synthesis of (±)-talaromycin B via a stereoselective cation-olefin cyclisation step
✍ Scribed by I.Trevor Kay; David Bartholomew
- Book ID
- 104241357
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 203 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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