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Stereoselective synthesis of 3-(1-Hydroxyethyl)-2-azetidinonesfrom 3-hydroxybutyrates

✍ Scribed by Gunda I. Georg

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
206 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis

Addition of dianions of 3-hydroxybutyrates to benzylideneaniline results in direct formation of trans S*-3-(1-hydroxyethyl)-1,4-diphenyl-2-azetidinone with 95% diastereoselectivity. Inversion of theconfiguration at C, gives the desired trans R*-2-azetidinone in high yield. --

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