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3-(1′-hydroxyethyl)-2-azetidinones from 3-hydroxybutyrates and n-arylaldimines

✍ Scribed by Gunda I. Georg; Harpal S. Gill; Cathy Gerhardt

Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
213 KB
Volume
26
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Dianion imine addition, cyclisation reaction between ethyl-3-hydroxyhutyrate and aldimines generates +lactams

with the hydroxyethyl sidechain of thienamycin and related B-lactam antibiotics in place.

The effects of the N-arylaldimine and the reaction conditions on the sterochemistry of the resulting products are examined.

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