Stereoselective Synthesis and Isomerization of the Indole Alkaloid Murrayacarine (IV).
โ Scribed by Ann-Louise Johnson; Johnny Slaett; Tomasz Janosik; Jan Bergman
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 19 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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The tetrahedrane framework with R=tBu and the octabisvalene framework with R = CH3 presumably form because of steric reasons. Whereas the hydrocarbon 2 is highly strained, the arrangement in 1 is largely strain-free, based on the intermolecular contact distances. With other residues R the occurrenc
The total synthesis of3 the %z&no~ indole alkaloid tubifoline and detailed H-and C-NMR data of thisalkaloid are reported. ## Tubifoline is a pentacyclic Stigchao~ indole alkaloid, 1 having the Strychnan skel-eta1 type, whose isolation and structural elucidation were reported by Schmid in 1964. 2